Interestingly, CD8+ T cells was not positively correlated with neoantigens in TP53 C-LOH subgroup (Fig. 5f), and further analysis revealed that the infiltration of CD8+ T cells was independent of p53 status (Supplementary Fig. S4), which indicated that neoantigens might not trigger anti-tumor immune response in this subgroup of GC. The gene discussed is CD8A; the disease is neoplasm.