In addition, increased JIP3 expression promoted a significant peripheral redistribution of lysosomes in non-malignant cells, but not in the cancer cells which already exhibit peripheral lysosome positioning [3] and high amounts of JIP4 expression that would also be aided by the increases in kinesin-1 (KIF5C, KLC2) and regulatory protein ARF6 expression. The gene discussed is SPAG9; the disease is cancer.