In the colon cancer cell lines, shown in Fig. 6A–C, the transcriptional program controlled by c-Myc was the most specific and the least redundant, as the majority of its target mRNAs were not co-controlled or taken over by mutant KRAS and p53 when co-expressed with c-Myc (Fig. 6A). Here, TP53 is linked to malignant colon neoplasm.