FILIP1L and neoplasm: In addition, it has been shown that the knockout of FILIP1L gene leads to pulmonary adenoma formation in mice; suggesting that repression of FILIP1L is an important event during initiation or early progression of lung adenocarcinomas (54) LZTL1 regulates ciliary localization of the BBSome complex (55) and may have tumour suppressor function in several primary cancer types (56).