In the conventional high dose (50 μg/kg) caerulein model we observed substantial, statistically significant differences in important biochemical parameters characterizing the severity of AP; serum AMY (amylase), pancreatic MPO (myeloperoxidase; PMPO) and pancreatic trypsin in ATG16L1[E230] mice were increased in comparison with WT littermates (Figure 2). This evidence concerns the gene ATG16L1 and alkaline phosphatase measurement.