The results of the current study confirmed, that similarly to LAP and CASM [39,40,43,44,51], LNCA requires a functioning WDD of ATG16L1; genetic deletion of the WDD results in the loss of LNCA and increase in the severity of caerulein -induced AP, suggesting that LNCA plays a protective role in AP. This evidence concerns the gene LSM1 and alkaline phosphatase measurement.