ATG16L1 and alkaline phosphatase measurement: Indeed, in the moderate model of AP (induced by caerulein injections of 25 μg/kg) the levels of serum AMY, intrapancreatic trypsin, PMPO and IL6 were substantially and significantly increased in WDD and LNCA-deficient ATG16L1[E230] mice (Figure 3), while the p value for LMPO was 0.054 (i.e. close to the threshold for statistical significance).