In eleven patients with hypopituitarism and untreated GHD, the daily dose of hydrocortisone was reduced from 20 to 30 mg to 10–15 mg, and after one year there were positive effects on body fat (especially abdominal fat) and lipid profile (reduction in total cholesterol and triglyceride levels), but not on lean body mass and insulin sensitivity. This evidence concerns the gene INS and hypopituitarism.