Finally, Qi et al. showed that SIRT5‐mediated desuccinylation blocks PKM2 translocation from nucleus to mitochondria and the consequent interaction with dependent anion channel 3 (VDAC3), which is then degraded and leads to higher mitochondrial permeability and apoptosis in CRC cells.148. This evidence concerns the gene SIRT5 and colorectal carcinoma.