Low expression is often positively correlated with the occurrence and development of diseases.12,23 In this study, increasing the expression of HSPB8 or BAG3, or activating autophagy, can suppress the expression of Filamin A. Furthermore, Filamin A could inhibit the migration and invasion of ICC cells, but this inhibition could be reversed by HSPB8 or BAG3. Here, BAG3 is linked to intrahepatic cholangiocarcinoma.