It acts as a co-molecular chaperone of HSPB8 to mediate CASA.8 In gastric cancer, BAG3 enhances the proliferation and invasion of cancer cells through the ERK/EGR1 pathway.9 In colorectal cancer, the overexpression of BAG3 not only promotes cell growth, migration, and invasion but also enhances the resistance of cancer cells to the chemotherapeutic drug 5-FU, thereby improving tumor survival.10 BAG3 plays a significant role in various types of cancers, but its role in ICC has not been investigated. This evidence concerns the gene HSPB8 and intrahepatic cholangiocarcinoma.