Molecular chaperones and co-chaperones could serve as potential targets for drug treatment of diseases.24 Based on this, we conducted experiments and discovered that the HSPB8-BAG3 chaperone complex can enhance ICC cell migration and invasion by regulating CASA-mediated degradation of Filamin A. This finding could potentially inspire the development of enhanced therapeutic strategies for ICC. The gene discussed is BAG3; the disease is intrahepatic cholangiocarcinoma.