BAG3 and colorectal cancer: It has been reported that the HSPB8/BAG3 pathway mediates CASA and induces autophagic degradation of denatured Filamin A under high cellular tension.8 A study has demonstrated that silencing Filamin A in colorectal cancer promotes cell migration and invasion, thereby facilitating cancer progression.11 Another study reported that Filamin A is downregulated in breast cancer, which suppresses the migration, invasion, and metastasis of breast cancer cells.12 A recent study found that Filamin A is cleaved by calpain to produce a 90 kDa fragment.