For example, HSPB8 is highly expressed in TNF-α-induced ovarian cancer and facilitates the migration of ovarian cancer cells.6 The researchers detected a higher expression level of HSPB8 in lung adenocarcinoma tissues and demonstrated that the elevated expression of HSPB8 promoted the proliferation and migration of lung adenocarcinoma cells.20 BAG3, a member of the Bcl-2 family, is a multifunctional accessory chaperone and anti-apoptotic protein. This evidence concerns the gene TNF and ovarian carcinoma.