In the development of colorectal cancer, thyroid cancer, and liver cancer, BAG3 can enhance the ability of cancer cells to metastasize, thereby complicating cancer treatment.21 Previous studies have shown that HSPB8 and BAG3 can combine to form a protein complex that regulates the CASA process, influencing cancer cell growth, migration, and apoptosis.4 However, there are few studies on the mechanism of action of the HSPB8-BAG3 complex on ICC progression. This evidence concerns the gene CSN1S1 and liver cancer.