BRD4 and primary biliary cholangitis: Several studies have shown that BRD4 is abnormally elevated in hepatic fibrosis tissues caused by various etiologies such as viral hepatitis infections (hepatitis C virus (HBV), hepatitis C virus (HCV)), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), cholestasis, and alcohol-associated liver disease (ALD) [205, 206].