Several studies have shown that BRD4 is upregulated in a variety of renal diseases, including hyperuricemia nephropathy [242], focal segmental glomerulosclerosis (FSGS), LgA nephropathy [243], renal IRI [244], unilateral ureteral obstruction(UUO) renal injury [245], HN [246], diabetic kidney disease (DKD) [247], and renal cell carcinoma (RCC) [248]. This evidence concerns the gene BRD4 and focal segmental glomerulosclerosis.