FOXO3 and Alzheimer disease: PIK3CA and AKT1 are crucial kinases in the PI3K/AKT signaling pathway, which regulates multiple pathways for AD treatment, including reducing inflammatory factors’ expression levels in AD mice by regulating downstream FoxO3a, improving hyperphosphorylation of tau in AD rats, and promoting proliferation of AD model cells by regulating downstream GSK-3β [32, 33].