We identified significant colocalization events between human VSMC expression quantitative trait loci (eQTLs) and signals in genome-wide association studies for coronary artery disease (CAD) for 13 human orthologs of the 50 genes with the highest rewiring scores (for example, KLF2/4/13/15, HEYL, TCAP, S100A10, VCAM1; Supplementary Table 1d,e), indicating causality of VSMC regulatory rewiring in disease. This evidence concerns the gene KLF2 and coronary artery disorder.