Mechanistically, LTβR-derived signaling cascades and subsequent chemo-/cytokine production are required for the recruitment of different immune cells which cooperatively promote tumorigenesis in both, AKT/β-catenin-derived intrahepatic cholangiocarcinoma and in LTβ-hepatocyte-specific overexpression-derived HCC [8, 22–24]. The gene discussed is LTBR; the disease is hepatocellular carcinoma.