Collectively, these results show that the main functional outcome of LTβR activation in cancer cells is the secretion of chemo-/cytokines, that this requires the LUBAC- and linear ubiquitin-dependent activation of canonical NF-κB and that LTβR stimulation is not capable of inducing the death of these cells even in the absence of linear ubiquitination. Here, NFKB1 is linked to cancer.