LTBR and hepatocellular carcinoma: Furthermore, conditional deletion of LTβR in hepatocytes or whole-body ablation of LIGHT abrogated hepatocarcinogenesis by inducing a substantial decrease in proinflammatory chemo-/cytokine production and liver infiltration by CD8 and natural killer T (NKT) cells in a long-term choline-deficient high-fat diet-driven HCC model in mice [25].