In order to elucidate whether Schwann cells were activated by cervical cancer cells and then initiate PNI, together with the underlying mechanisms, we screened the expression of genes in cervical cancer cells in the co-culture system with nerve, and found the tumor-derived neuropeptide, neuromedin B (NMB), in the activation of Schwann cells, induction of axon regeneration, and initiation of PNI. The gene discussed is NPS; the disease is cervical cancer.