The co-localization of NMBR and GFAP were observed in tumor-invading sites of sciatic nerve (Fig. 4a), with a Pearson’s colocalization coefficient of 0.41 and 0.81 in Hela and ME180 PNI models (Fig. 4b, c), presenting that NMBR is located in activated Schwann cells. Here, NMBR is linked to neoplasm.