Meanwhile, a coronary artery disease-associated m.15927G > A mutation led to variable decreases in the levels of ND1, ND3, ND4, ND5, CO2, CYTB, ATP6, and ATP8, whereas ND6 with lower threonine codons and nuclear genes encoded subunits NDUFB8, SDHB, UQCRC2 and ATP5A in mutant cybrid cell lines were comparable with those in control cells (17, 35). Here, MT-ND4 is linked to coronary artery disorder.