Analysis of BNIP3 and BNIP3L/Nix expression in cybrid cell lines harboring two LHON-associated 11778G > A and 3460G > A LHON mutations revealed that BNIP3 protein level is decreased in LHON cells compared to controls (47). The gene discussed is BNIP3L; the disease is Leber hereditary optic neuropathy.