ISG15 and Granuloma: Relative to naive granulomas, IgG granulomas had lower expression of cytotoxic effector (GZMA, GZMB), hypoxia-induced factors (HIF1A, BHLHE40, ENTPD1),40 T1T17-like transcription factors (TFs) (RORA, RORC), and interferon (IFN)-stimulated genes (ISG15, MX1) across several T, NK subsets (Figures 4C and S3D).