,55 IgG granulomas—characterized by reduced neutrophilia—did not support the same level of bacterial growth or dissemination as naive lesions and inhibition of Mtb growth, and dissemination post-reinfection was at least partially CD4+ T cell-dependent and independent of CD4+ T cell-mediated induction of myeloid IFN-γ and TNF response pathways. Here, TNF is linked to Granuloma.