Myeloid cells from naive granulomas featured both global and subpopulation-specific increases in expression of IFN-stimulated genes (ISG15, ISG20), pro-inflammatory mediators (IL1A, ILB), chemokines and cytokines including the CXCR3 ligands (CXCL9, CXLC10, CXCL11), fibrosis-related genes (VEGFA, TGFB1), and immunoregulatory molecules (IDO1, CD274 (PD-L1), IL10) relative to macrophages in IgG granulomas (Figures 5E, 5F, and S4D). The gene discussed is ISG15; the disease is Granuloma.