In keeping with these findings, we observed reinfection (IgG) granulomas, enriched for IL10 sender T, NK cells, experienced significant blunting of type 1 inflammation and type 1 IFN signaling, and decreased frequencies of M1- and interstitial-like macrophages relative to primary infection (naive) and αCD4 granulomas. The gene discussed is IL10; the disease is Granuloma.