Most of literature stated that Pleomorphic adenoma cannot invade bone, this is not caused by bony invasion but rather by the inelasticity of the palatal mucosa, which becomes distended by the tumor mass and may eventuate in a cupped out resorption of bone by activating RANK, RANKL, OPG mechanism [11]. The gene discussed is TNFRSF11A; the disease is neoplasm.