Importantly, in addition to a role for Rab27 in OROV egress, we have further demonstrated that the Rab27 effector MyoVa colocalizes with OROV positive structures over the course of infection (S5 Fig), and the inhibition of OROV release in MyoVa depleted cells (Figs 6 and 7), similar to the observed for HSV-1 egress [53]. The gene discussed is RAB27A; the disease is infection.