AKT1 and neuropathy: After collating data on the 6 most commonly occurring AEs (diarrhea, fatigue, nausea, rash, neuropathy, and alopecia), we observed that while the AKT inhibitors in combination with paclitaxel or atezolizumab demonstrated slightly better improvement than the placebo therapy arm, patients in the new combination treatment arm experienced a higher incidence of diarrhea and nausea.