However, it is noteworthy that Peng Tan et al conducted a bioinformatics analysis and identified the MMP25-AS1/hsa-miR-10a-5p/Serpin Family E Member 1 axis as a novel prognostic biomarker associated with immune cell infiltration in KIRC.[53] This pathway has the potential to modulate the expression of chemokines (CCL4, CCL5, CXCL13, and X-C Motif Chemokine Ligand 2), thereby influencing the tumor immune microenvironment and the development of KIRC. The gene discussed is XCL2; the disease is neoplasm.