KEGG pathway analysis showed that DEmRNAs were mainly enriched in PI3K-Akt signaling pathway, microRNAs in cancer, MAPK signaling pathway, cellular senescence, rheumatoid arthritis, Ras signaling pathway, fluid shear stress and atherosclerosis, cell adhesion molecules, focal adhesion, Th17 cell differentiation, proteoglycans in cancer, Rap1 signaling pathway, p53 signaling pathway (Fig. 8D). Here, TP53 is linked to cancer.