Consistent with tumor suppression, effectors of tumorigenesis (Myc, Myb, NKX2-3, and TRIM24), metastasis (NFE2L2), oncogenic transformation (FOXM1), and cell cycle (E2F2 and E2F3) were also inhibited in the presence of PRKN (Supplemental Figure 1B). This evidence concerns the gene E2F3 and neoplasm.