Consistent with this, reexpression of PRKN in prostate cancer DU145 or pancreatic adenocarcinoma PANC-1 cells increased IFN-γ mRNA levels (Supplemental Figure 1I), whereas PRKN siRNA silencing in MCF10A cells suppressed IFN-γ expression (Supplemental Figure 1J). This evidence concerns the gene IFNG and prostate carcinoma.