E2F2 and neoplasm: Consistent with tumor suppression, effectors of tumorigenesis (Myc, Myb, NKX2-3, and TRIM24), metastasis (NFE2L2), oncogenic transformation (FOXM1), and cell cycle (E2F2 and E2F3) were also inhibited in the presence of PRKN (Supplemental Figure 1B).