In a first series of experiments, we crossed Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice, which express the SV40 large T antigen oncogene in the prostate under the control of the probasin promoter (39) with PRKN-knockout (PRKN-KO) mice (27). The gene discussed is PRKN; the disease is adenocarcinoma.