PRKN and Familial prostate cancer: By RNA-Seq profiling, we found that transient expression of PRKN in PRKN-negative prostate cancer PC3 cells (30) induced a potent IFN response (Figure 1, A and B) with upregulation of multiple IFNs, ISG, and pleiotropic cytokines (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI180983DS1).