PSEN2 and melanoma: Specifically, high expression of 4 key CRGs (ABCC2, CA14, LDHB, PSEN2) was significantly correlated with poor prognosis in melanoma patients (HR>1, P<0.05), while low expression of 2 key CRGs (EGR3, FBXW7) was significantly associated with poor prognosis (HR<1, P<0.05) (Figure 6A–6F).