IFNG and herpes simplex infectious disease: Furthermore, because IFNγ plays a central role in host defense, anti-tumor immunity, and autoimmunity (Kwon, 2018; Pollard et al., 2013), results from our study suggest that tissue-resident fibroblasts may play a role in shaping the development of type-1 immune response in other diseases, such as infectious diseases (such as herpes simplex), cancer, and autoimmune disorders, such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.