GO pathway analysis of CD4+ and CD8+ T cell clusters revealed that chemokine signaling and type II interferon signaling pathways were among the top upregulated, and TGFβ and PI3K-Akt-mTOR signaling were among the top downregulated pathways in ACD compared control (Figure 2E). The gene discussed is MTOR; the disease is granular corneal dystrophy type II.