To further compare and contrast the effects of sotorasib and DCC-3116, either alone or in combination in GEM models of lung cancer and because of noted correlations between loss of LKB1 and insensitivity of cancers to various types of therapy, we employed our KP mouse model (Shackelford et al., 2013; Pons-Tostivint et al., 2021). This evidence concerns the gene STK11 and lung cancer.