Whether this reflects the ability of LKB1 signaling to (1) regulate cancer metabolism through effects on triosephosphate isomerase or altered lactate production and secretion, (2) regulate transcription effects on histone acetylation via elevated CRTC2-CREB signaling downstream of the salt-inducible kinases or effects on HDAC1/3 or some other signaling circuit remains to be determined (Stein et al., 2023; Eichner et al., 2023; Hollstein et al., 2019; Shackelford and Shaw, 2009; Qian et al., 2023; Compton et al., 2023). The gene discussed is CRTC2; the disease is cancer.