To test whether combined inhibition of KRASG12C plus ULK1/2 would inhibit growth of established KRASG12C/LKB1Null lung tumors, tumor-bearing KL mice at 10 weeks p.i. were administered sotorasib or DCC-3116 either alone or in combination for 8 weeks or until the mice met predetermined euthanasia endpoints (Figure 4D). Here, DCC is linked to neoplasm.