As expected based on analysis of human KRASG12C-driven lung cancer cells, KL70 cells increased autophagy in response to either sotorasib or trametinib treatment, a further demonstration that LKB1 is not required for increased autophagy in response to inhibition of KRASG12C>RAF>MEK>ERK inhibition (Figure 6E). This evidence concerns the gene STK11 and lung cancer.