We and others have previously reported that inhibition of RAS>RAF>MEK>ERK signaling in melanoma or pancreatic cancer cells elicits increased autophagy, an intracellular macromolecule and organelle recycling mechanism, through the LKB1>AMPK>ULK1 signaling axis (Silvis et al., 2023; Truong et al., 2020; Kinsey et al., 2019; Bryant et al., 2019). Here, STK11 is linked to pancreatic neoplasm.