RNASE3 and eosinophilic esophagitis: Several studies have targeted eosinophil-specific proteins as potential biomarkers for diagnosis and disease monitoring.27,28,36–44 In a systematic review of Radonjic et al,45 eotaxin-3, TARC, AEC, ECP, and mast cell tryptase were identified as potential candidates to discriminate between active EoE and EoE in remission after treatment.