Manzhalii et al. have more recently demonstrated a clear correlation with increases in inflammatory cytokines IL-1β, IFN-γ, IL-6 and IL-4 with increasing HE grade in patients with Child–Pugh B cirrhosis as well as in their rat model when compared with controls (Manzhalii et al. 2019). The gene discussed is IL1B; the disease is hereditary elliptocytosis.