TARDBP and dementia: In the participants without clinical symptoms of dementia the following was observed: 12% presented the misfolded α-syn and Aβ; 11% of patients presented the misfolded α-syn and Tau; 3% of patients presented the misfolded α-syn and TDP-43; more than 19% of patients presented the misfolded α-syn, Aβ and Tau; and 2% of patients presented with α-syn, Tau, and TDP-43 or α-syn, Aβ, and TDP-43 [9].