RNA-seq data from wild-type and ATF3 knockout A549 human lung adenocarcinoma cells either mock-infected or infected with ZIKV PRVABC59 at a moi of 10 PFU/cell and harvested at 24 hours post-infection have been deposited in Gene Expression Omnibus (GEO) at GSE233049. The gene discussed is ATF3; the disease is infection.