The third intron retention candidate, WD Repeat And FYVE Domain Containing 1 (WDFY1) enhances the production of inflammatory factors or IFN‐β by positive regulation of TLR3‐ and TLR4 signalling pathways and activation of NF‐κB,32 thereby promoting progression of melanoma,33, 34 and other serious types of cancer.35 This evidence concerns the gene TLR4 and melanoma.