BRAF and brain neoplasm: Brain tumors are the most common type of solid tumor and cause of cancer-related death in children.1 Pediatric low-grade gliomas (pLGGs) are gradually progressing brain tumors that originate from glial cells and are categorized as World Health Organization grades I or II,2 accounting for 30–50 percent of all childhood central nervous system tumors.3 Collectively, pLGGs represent a basket of >20 histologies4 and, more recently defined, heterogeneous molecular characteristics,5 with nearly 50% of tumors harboring a BRAF-associated mutation.6