Using a preclinical stress-induced migraine model (18), we employed pharmacological tools such as metyrapone, an 11-beta hydroxylase inhibitor that blocks the conversion of deoxycorticosterone to corticosterone, and mifepristone, a glucocorticoid receptor antagonist commonly used in clinical and preclinical studies to assess the role of CORT synthesis and signaling in response to repeated stress. The gene discussed is CORT; the disease is migraine disorder.