RYR1 and edema: To identify the causative genes in the 3rd hydrops fetuses, we performed whole exome sequencing on the umbilical cords of the hydrops fetuses of II4 and II5 pregnancies and the peripheral blood of the parents and identified a new shear variant mutation c.538-33C > A in intron 6 of the RYR1 gene, which belongs to the deep intronic mutation region affecting shear.