TNNT2 and familial dilated cardiomyopathy: Most of the cTnT mutations induced changes either in the flexibility of cTnT or in the Ca2+ affinity for the cTnC calcium-binding site, thus contributing to HCM, RCM, DCM, or left ventricular non-compaction cardiomyopathy phenotypes.105, 106, 107, 108, 109, 110 The location of the cTnT mutation contributes to the type of alterations in protein properties.108