Using the ESTIMATE algorithm to assess the stromal and immune score across 33 cancer types, we found that ITPRIPL1 expression is strongly positively correlated with these scores in LUAD, PAAD, LIHC, BRCA, CHOL, KIRC, THCA, KICH, ACC, and PCPG, while negative correlations were observed in LAML and GBM. This evidence concerns the gene ITPRIPL1 and cancer.