CD8A and pancreatic adenocarcinoma: The expression level of ITPRIPL1 is strongly positively correlated with various immune cells, including activated CD8+ T cells, CD56bright natural killer cells, effector memory CD8+ T cells, natural killer cells, T follicular helper cells, type 1 T helper cells, and myeloid-derived suppressor cells (MDSCs) across multiple types of cancer, particularly in PAAD with P < 0.001 and Spearman r value greater than 0.7 for all (Figure 4C).