BRIP1 and breast cancer: Rafnar et al. (2011) confirmed that BRIP1 gene was one of the representative tumor suppressor genes in ovarian cancer, suggesting that this mutation in BRIP1 gene may also increase the risk of other cancers. Similarity, it had also been reported that the expression of BRIP1 was increased, which was easy to cause breast cancer and had a significant effect on the reproductive function of female mammals (Zou et al., 2016; Gupta et al., 2017). Moreover, this study also found that the frequency distribution of 9 SNPs of BRIP1 gene was quite different in the world sheep.