The ECS consists of cannabinoid receptors (CB1 and CB2) and endogenous cannabinoids (endocannabinoids) that bind to these receptors.18 By targeting the ECS, cannabis may modulate pain signaling pathways and reduce pain intensity.22 Research suggests that cannabis may act a potential analgesic agent, providing relief to individuals with chronic pain, including those with endometriosis (Fig. 1).23–24. Here, CNR2 is linked to endometriosis.