RHOH and glioblastoma: TTF are hypothesized to disrupt mitosis through microtubule depolymerization and aberrant spindle formation, precluding the formation of viable daughter cells.17 Preclinical models of nonsmall cell lung cancer and GBM have explored TTF + XRT concomitantly or in close temporal succession, and demonstrated synergistically increased apoptosis, DNA damage, mitotic abnormalities, as well as suppression of cell migration and invasiveness.10–12