Like other lncRNAs such as HOTAIR in breast cancer (Bhan et al., 2013; Portoso et al., 2017; Ma et al., 2022) and MALAT1 in lung cancer (Amodio et al., 2018; Liu J. et al., 2023; Bhat et al., 2024), ST8SIA6-AS1 could interact with chromatin-modifying proteins to influence gene expression epigenetically. The gene discussed is ST8SIA6; the disease is breast cancer.