Additionally, the fatty acid binding protein encoding FABP4, which has been reported to be downregulated by Wnt/β-catenin signaling activation (Gastfriend et al., 2021b) and is depleted in CNS vascular endothelial cells (Sabbagh et al., 2018) was significantly upregulated in ALS patient (TARDBPN345K/+)-derived EECM-BMEC-like cells. This evidence concerns the gene FABP4 and amyotrophic lateral sclerosis.