When culturing EECM-BMEC-like cells in an SMLC-conditioned medium, ALS patient (TARDBPN345K/+) -derived EECM-BMEC-like cells expressed cell surface ICAM-1 under nonstimulated conditions, which is enhanced upon proinflammatory cytokine stimulation (Figure 4A). The gene discussed is ICAM1; the disease is amyotrophic lateral sclerosis.