TARDBP and amyotrophic lateral sclerosis: These results indicate that TARDBPN345K/+ EECM-BMEC-like cells mimic the tight junction discontinuation observed in ALS patients’ autopsied CNS samples, however, the TARDBP gene-edited model (TARDBPK263E/K263E and TARDBPG295S/G295S) did not recapitulate the disrupted tight junctions.