TARDBP and amyotrophic lateral sclerosis: Notably, RNA transcripts and nuclear proteins analysis showed that the brain capillary endothelial cells from patients with ALS or frontotemporal lobar degeneration (FTLD) expressed reduced levels of TDP-43 and nuclear β-catenin along with diminished expression of canonical Wnt response genes, which is important for BBB development and maintenance (Omar et al., 2023).