NOTCH1 and osteoarthritis: In terms of cartilage metabolism, studies have established a murine model of osteoarthritis by destabilizing the medial meniscus, finding that Itch degrades JAG1 via ubiquitination, inhibiting the activation of the Notch1 pathway, thereby reducing endotoxin-induced chondrocyte damage and osteoarthritic articular cartilage damage, offering new strategies for osteoarthritis treatment (Qi et al., 2022).