Smurf2 regulates angiogenesis by promoting the ubiquitination and degradation of Pentraxin 3 (PTX3), highlighting the role of E3 ubiquitin ligases in the abnormal angiogenesis associated with ankylosing spondylitis pathology (Ma et al., 2021). This evidence concerns the gene SMURF2 and ankylosing spondylitis.