By regulating the expression of miR-125a-5p and TNFAIP3, the long non-coding RNA (lncRNA) MEG3 affects osteogenic differentiation of mesenchymal stem cells; overexpression of MEG3 and TNFAIP3 or inhibition of miR-125a-5p can suppress the osteogenic differentiation of BMSCs, offering new strategies for the treatment of ankylosing spondylitis (Liu C et al., 2023). Here, TNFAIP3 is linked to ankylosing spondylitis.