CBR3 and gastrointestinal disease: Cyp2b10 and Cyp2b19 are members of the CYP450 enzyme family (Gethings et al., 2021), in T2DM-induced gastrointestinal diseases, Cbr3 negatively regulates the expression of Cyp2b10 and Cyp2b19 proteins, resulting in elevated protein expression.