Prospective, real time, investigator initiated, observational multicenter study, patients admitted to the ICU with sepsis and septic shock.45 patients were included and SOFA score was 12.90 (4.02).In the survivor group, the percentage dose reduction in vasopressor was norepinephrine (51.4%), epinephrine (69.4%) and vasopressin (13.9%) and a reduction in IL-6 levels (52.3%) was observed in the survivor group. This evidence concerns the gene IL6 and Sepsis.