Cytosorb® registry, 1,434 patients.Indications for HA were sepsis/septic shock (n = 936); cardiac surgery perioperatively (n = 172); cardiac surgery postoperatively (n = 67) and “other” reasons (n = 259).At the end of HA, 80.6% of patients were alive. However, there was no significant difference in the predicted and actual hospital mortality. Just as in the whole cohort both the cardiovascular and the pulmonary subscores improved significantly and changes could be determined for CRP in 67.5%, PCT in 45.5% and IL-6 in 20.0% of patients. The gene discussed is CRP; the disease is Sepsis.