Considering these interaction patterns and the risk levels of gene alterations, we defined two main DLBCL genetic subtypes, the high-risk H1 subtype characterized by MYD88 L265P, CDKN2A and TBL1XR1 alterations and the low-risk L1 subtype characterized by SGK1, SOCS1 and GNA13 alterations. Here, MYD88 is linked to diffuse large B-cell lymphoma.