In addition, studies have found that gut commensal streptococci in infant AD patients are positively correlated with IgE and SCORAD indices, possibly through interactions with gut epithelial cells, which influence the progression of AD in infants through the release of inflammatory factors and reduction of short-chain fatty acids (SCFAs) (Sadowy and Hryniewicz, 2020; Kang et al., 2021). The gene discussed is IGHE; the disease is Alzheimer disease.