Additionally, a preclinical tumor study showing ectopic expression of TCF1 skews TILs to adopt a TSL phenotype while enhancing their polyfunctionality and further suppressing inhibitory receptors and modulating the transcriptome to further suppress TFs like BLIMP1, RUNX3, and TOX to improve viral and tumor control (38). The gene discussed is RUNX3; the disease is neoplasm.