IL32β was the most abundant isoform transcribed in CD3+ T cells from healthy individuals but also in intratumoral CD4+ Th subsets and circulating TA-specific CD4+ Teff from breast cancer patients, CD4+ and CD8+ MILs from a multiple myeloma patient and TA Survivin-specific CD8+ Teff cells. Here, CD8A is linked to plasma cell myeloma.