Indeed, increased IL-32 levels correlate with infectious diseases (3, 4), acute and chronic inflammation (1) and inflammation-related diseases, like skin inflammation (49), allergy (50) and atherosclerosis (51), but also cancer development (7) and disease progression in several autoimmune disorders, like Rheumatoid Arthritis (RA), Inflammatory Bowel Disease and Type 1 Diabetes (15). Here, IL32 is linked to type 1 diabetes mellitus.