For example, diabetes is suppressed with administration of a plasmid encoding ChgA, IGRP, GAD65 and insulin antigens, and targeting DβH233-241, ZnT8158-166, ZnT8282-290 and proinsulin with a plasmid approach provides better disease protection than proinsulin alone (258, 259). The gene discussed is CHGA; the disease is diabetes mellitus.