However, it was also shown that the total frequency and proportion of CD44highCD62Llow InsC-ChgA- and InsC-IAPP-specific CD4+ T cells in peripheral blood of NOD mice increases over time with disease onset much more robustly than InsB9-23-specific CD4+ T cells, strongly implicating these two hybrid peptide-reactive populations in diabetes pathogenesis. The gene discussed is CD4; the disease is diabetes mellitus.