hydrogen improves the 7-day survival rate, decreased the protein content in BALF, lung wet-to-dry ratio and lung MPO activity, reduces acute lung injury as well as liver and kidney injury in sepsis, increased the level of CAT and SOD, decreased the level of 8-iso-PGF2α and HMGB1, compared with the Sham group, mitochondrial dysfunction was alleviated in hydrogen groups. This evidence concerns the gene HMGB1 and Sepsis.