EGFR and Airway obstruction: Evidence of the AhR-EGFR pathway involvement was provided by an asthma mouse model study, showing that Benzo(a)pyrene (BaP)-induced AhR activation and ROS elevation led to the increased epithelial TGF-α production and MUC5AC expression, and activation of EGFR/MAPK signaling, thus causing airway obstruction and asthmatic distress (101).