The EGFR-AhR interaction has also been linked to cellular response to UVB stress and the development of skin tumors through the mechanism involving UVB-induced formation of the natural AhR ligand 6-formylindolo[3,2-b]carbazole (FICZ) in the skin which leads to c-Src-dependent EGFR internalization and ERK activation (98). Here, EGFR is linked to skin neoplasm.