SACS and spastic ataxia: The qPCR analysis confirmed the poly(I:C) induction of tlr7, ATP-dependent RNA helicase lgp2 (dhx58), activating transcription factor 3 (atf3), interleukin 1 beta (il1b), interferon alpha/beta receptor 2 (ifnar2), interferon-induced GTP-binding protein Mx-like (mx1), radical S-adenosyl methionine domain containing 2 (rsad2), ch25ha, trim25, trim16, ADAM metallopeptidase domain 22 (adam22), and spastic ataxia of Charlevoix-Saguenay (sacsin)-like (sacs-like) (Figure 4).