LAG3 and bladder transitional cell carcinoma: It was revealed that ADAM10 expression was negatively associated with numerous immune regulatory genes, such as C-C motif chemokine ligand (CCL)27, CCL14, CCL25, C-X-C motif chemokine receptor 5 (CXCR5), HLA-B, HLA-DOB1, LAG3, TNF receptor superfamily member 18 (TNFRSF18), and TNF receptor superfamily member 4 (TNFRSF4) in bladder urothelial carcinoma (BLCA), thymoma (THYM), breast invasive carcinoma (BRCA), TGCT, kidney renal papillary cell carcinoma (KIRP), SKCM and thyroid carcinoma (THCA) (Figure 6A).