It was revealed that ADAM10 expression was negatively associated with numerous immune regulatory genes, such as C-C motif chemokine ligand (CCL)27, CCL14, CCL25, C-X-C motif chemokine receptor 5 (CXCR5), HLA-B, HLA-DOB1, LAG3, TNF receptor superfamily member 18 (TNFRSF18), and TNF receptor superfamily member 4 (TNFRSF4) in bladder urothelial carcinoma (BLCA), thymoma (THYM), breast invasive carcinoma (BRCA), TGCT, kidney renal papillary cell carcinoma (KIRP), SKCM and thyroid carcinoma (THCA) (Figure 6A). Here, CXCR5 is linked to bladder transitional cell carcinoma.